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sirt1 inhibitor ex527  (TargetMol)


Bioz Manufacturer Symbol TargetMol manufactures this product  
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    Structured Review

    TargetMol sirt1 inhibitor ex527
    Sirt1 Inhibitor Ex527, supplied by TargetMol, used in various techniques. Bioz Stars score: 94/100, based on 11 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/sirt1 inhibitor ex527/product/TargetMol
    Average 94 stars, based on 11 article reviews
    sirt1 inhibitor ex527 - by Bioz Stars, 2026-02
    94/100 stars

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    Selleck Chemicals inhibitor of sirt1 ex527
    API enhanced <t>SIRT1</t> and HIF1α expression in the OBs. OP-BMSCs were differentiated into the OBs for 5 d (a) Protein expression of SIRT1 and HIF1α. (b, c) Quantification of SIRT1 and HIF1α expression ( n = 3). (d) IF assay SIRT1 expression. (e) Quantification SIRT1 IF intensity ( n = 3). (f) IF assay HIF1α expression. (g) Quantification HIF1α IF intensity ( n = 3).
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    API enhanced SIRT1 and HIF1α expression in the OBs. OP-BMSCs were differentiated into the OBs for 5 d (a) Protein expression of SIRT1 and HIF1α. (b, c) Quantification of SIRT1 and HIF1α expression ( n = 3). (d) IF assay SIRT1 expression. (e) Quantification SIRT1 IF intensity ( n = 3). (f) IF assay HIF1α expression. (g) Quantification HIF1α IF intensity ( n = 3).

    Journal: Fundamental Research

    Article Title: Apigenin alleviates osteoporosis by orchestrating SIRT1/HIF1α signaling in mesenchymal stem cells

    doi: 10.1016/j.fmre.2024.02.002

    Figure Lengend Snippet: API enhanced SIRT1 and HIF1α expression in the OBs. OP-BMSCs were differentiated into the OBs for 5 d (a) Protein expression of SIRT1 and HIF1α. (b, c) Quantification of SIRT1 and HIF1α expression ( n = 3). (d) IF assay SIRT1 expression. (e) Quantification SIRT1 IF intensity ( n = 3). (f) IF assay HIF1α expression. (g) Quantification HIF1α IF intensity ( n = 3).

    Article Snippet: Fig 5 To explore the underlying mechanism of API improvement in bone metabolism, we introduced a specific inhibitor of SIRT1 (EX527, 1 μM; Selleck, China).

    Techniques: Expressing

    API upregulated SIRT1 to stabilize HIF1α expression in the OBs. OP-BMSCs were differentiated into OBs. (a) ALP staining of OB after 7 d (b) Quantification of AKP activity ( n = 3). (c) ARS staining of OB after 14 d. (d) Quantification of ARS ( n = 3). (e) The protein expression of SIRT1, HIF1α and β-actin in the OB at 5 days. (f, g) Quantification of SIRT1 and HIF1α expression in OB after 5 d ( n = 3). (h) Images of femur SIRT1 IHC staining. (i) Quantification of SIRT1-positive cells staining ( n = 5).

    Journal: Fundamental Research

    Article Title: Apigenin alleviates osteoporosis by orchestrating SIRT1/HIF1α signaling in mesenchymal stem cells

    doi: 10.1016/j.fmre.2024.02.002

    Figure Lengend Snippet: API upregulated SIRT1 to stabilize HIF1α expression in the OBs. OP-BMSCs were differentiated into OBs. (a) ALP staining of OB after 7 d (b) Quantification of AKP activity ( n = 3). (c) ARS staining of OB after 14 d. (d) Quantification of ARS ( n = 3). (e) The protein expression of SIRT1, HIF1α and β-actin in the OB at 5 days. (f, g) Quantification of SIRT1 and HIF1α expression in OB after 5 d ( n = 3). (h) Images of femur SIRT1 IHC staining. (i) Quantification of SIRT1-positive cells staining ( n = 5).

    Article Snippet: Fig 5 To explore the underlying mechanism of API improvement in bone metabolism, we introduced a specific inhibitor of SIRT1 (EX527, 1 μM; Selleck, China).

    Techniques: Expressing, Staining, Activity Assay, Immunohistochemistry